I assume so because it's not listed under incompatibilities, but I know it's not compatible with RCRN due to their own little indoor lighting tweaks (which MDS does better, tbh). But the author is mainly supporting RLwC, so I'm not sure. (and there was a huge drama thread with RCRN vs RLwC I read earlier too...). But no mention of CoT, AFAIK.
Edit: so... I believe as long as CoT doesn't add their own little lighting balls indoors like RCRN was doing, it should be fine. And yes ENB is fully compatible.