Excuse my hyperbole in the earlier post. While I might "threaten" going with cracks, it's actually against my ethics and moral nature. I still occupy the position that if you have legitimately purchased a copy of software, you should be allowed to do with it whatever you want, as long as it remains in your possession, but that's a debate for some other time and forum. What I'm basically saying is while I actually considered trying to get the game running again by switching over to Nexus Mod Manager, I honestly wouldn't go with a crack for several reasons - some of which are articulated above. Thanks for your patience. Thank you all for such awesome advice. After many hours of tinkering and trying different things I've got Skyrim with MO working again. What I actually did (or if any of these things helped) remains an exercise in confused head-scratching. I was able to get SKSE to launch Skyrim last night, BUT only when using the -forcesteamloader in a shortcut I made to SKSE. It only worked one time. After that it was right back to the "Steam needs to be running" pop-up error box. Putting the command line switch into the argument box of MO's SKSE executable only gave me the Steam Load error message. Weird, huh? It was the same when I tried it this morning, too. No luck. I spent a bit more time on the WIKI MO page (thanks phazer11 for that!) and if nothing else, I'm a bit better versed in MO than I was a few hours ago. So I restarted my computer just a bit ago, and had a surprise when Steam actually asked me to log-in to my account. That hasn't happened since this problem began. I thought to myself, "could it be?" Yup - SKSE and my modded Skyrim game are both working fine again. I've started and exited the game 3 times now and all is well. It's very strange to me - I've got several games installed on this "dream machine" but the only one I really want to fire up at all is Skyrim. I bet there are a few readers of this who can totally relate.