I run spring cleaning, and the compat patch at the top of my load order along with Quest mods, I was and still might be getting 5-15minute crashes in game, most of them happen in city areas which makes sense as there is more spawns and objects happening I suppose. I have combinedobjects=1 in my INI file because that is meant to help with performance. Its a on going process for me solving CTD issues, lately MO2 has been falling over in the background causing the game to crash itself, then other times I will scratch my head with these random CTD issues. As for your question, again try the spring cleaning compat patch as he removes the combined objects for build areas, however I don't know how stable it is, still forever testing...