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I was doing some reading of issues on the Mod Organizer github and stumbled onto an issue the same as yours, crashing when launching applications through MO2. A couple of users there stated there they were using BitDefender Antivirus. They also stated that they were also using BitDefenders Advanced Threat Defense which is separate from the AV. It looks like one of the users outright disabled the threat defense and the other made some exceptions to the advanced threat defense. I took the liberty to copy them here in case you also use that. (MO2 Install Directory)\modorganizer.exe (MO2 Install Directory)\ufvfsZ_Zproxy_x64.ext (Skyrim special edition Install Directory)\skse64_loader.exe (Skyrim special edition Install Directory)\skyrimse.exe From <https://github.com/ModOrganizer2/modorganizer/issues/1808>

Yeah, I used ESET before in the past but it was part of a work license, so I do not have access to it anymore. I will corroborate that I had no issues back when I had ESET. Just glad this seems to be the fix we were looking for.

Mod was updated to version 1.18.0. Version 1.18.0 Fixed some parts of the ground in Windhelm were marked as “Unknown” material. Fixed some parts of the dirt ground in Windhelm were marked as “Heavy metal” material. Fixed a piece of imperial tower ring ground were marked as "None" material. Fixed dwemer mill gear assembly marked as "None" material. Added Patch for Golden Dwemer Pipeworks Redone.