First a confession : I didn't install all of F&L. Omitted some mods out of personal preference and included some of my own. But F&L is the best base for NV modding I've found so far and I've followed all relevant parts of the guide (i can hear someone grumbling right now). Not a total newb at modding, but this one has got me stumped. So, to the problem. I was getting seemingly random crashes while fast traveling/entering/exiting building. At the start of the game it could be two hours of playtime before I crashed. Then I got to Freeside (lots of cell transitions) and a pattern started emerging. Game would crash after 4-7 cell transitions without fail. Totally reproducible. Commence the mod debugging nightmare. Deactivate all non-F&L mods , rebuild bash , test , rinse repeat ... enb on/off ...the works. Fast forward a few days. Focus : NVSE plugins. And voila. Without NVAC i stopped testing transitions at 45+ successful ones. With NVAC enabled - 4-7 then CTD. Leaving it off made crashes in the open world quite annoying. Leaving it on made transitions a nightmare. I'm out of ideas here ... Setup: -i5,16gb,gtx6600,win10 x64 -fnv4gb -ENB Boost -fake fullscreen (game companion 2.4) -all relevant exes are run with elevated privileges Pastebins: Load order : https://pastebin.com/09F4Jtwb Activated Mods : https://pastebin.com/gXZsVCDF NVAC Log : https://pastebin.com/iVZZg46x EDIT : Same result if I disable stutter remover and leave NVAC enabled. No CTD's . I did something fishy there ... just no clue what.