Thanks for your answer
I already started Skyrim through the Steam launcher. It makes no difference.
So i checked everything. Cleaned my Overwrite, adjusted some settings with BethINI(didn't know that existed). The guide says the directory: C:\Users\{logged in user}\AppData\Local should not be used. But in the screenshots this directory stays for the mod location from MO2. Or is it only for installing MO2 itself? So can i just uninstall MO2 and install it in the new ..Games\Modding\Mod Organizer\ directory? Will everything i set up stay the same?
So far it's still crashing.