Hello akmatov :) I did this guide 3 times and I think I'm competent enough to answer you very simply. 1 question: just set both of them to "Application Controlled / Off" - it means application itself (in this case skyrim) will controll the filtering process not nvidia application. 2 question: so in first you allowed for skyrim to controll filtering right, now by setting ForceAntisotropicFiltering to TRUE you allow for ENB to controll filtering of skyrim, not skyrim itself will controll it. So yes ENBoost is needed even if you are not using Presets. It manages some other graphics settings also the antisotropic filtering. Long story short: in NVIDIA you allow filtering to be controlled by SKYRIM and later you allow ENBOOST to controll filtering. That's it. Why? Because probably ENBOOST is the best guy who can hadle filtering properly. :D I don't know ^^