65andhappy

I just had a similar experience. I installed a new game drive (SSD) and re-downloaded the game file from Steam. I set up Mod Organizer, NVSE and FNV 4GB Loader. I started the game from the Steam Program and generated the ini files. When I went to edit them I found all the ini tweaks already there. I tried starting through MO with the launcher, NVSE and 4GB Loader but it crashed each time. The start screen would begin to load then crash. This happened even with no plugins loaded (Fallout.esm only). I thought about the ini file and the tweaks, so I checked the ini files from the Documents\My Games\Fallout NV folder and low and behold - they were different than the default ones in SteamLibrary\steamapps\common\Fallout New Vegas\Mod Organizer\profiles\Default folder. So I copied the ini files from the Documents\My Games\Fallout NV folder and pasted them into the Mod Organizer folder. Then I test ran each of the launcher, NVSE and 4GB Loader loads through MO and Bingo the game loaded. I eneterd the tweaks and once again success. Somehow MO the MO inis were messed up. I am now happily coninuing adding mods.