First, I realize this sound absurd. Nothing in Occlusion.esp should be affecting NPC AI/Package. And yet, in my own testing, I find that the Occlusion.esp generated from DynDoLOD 3.0 Alpha is in fact preventing some Sandbox packages from working properly.
Specifically, I have a Sandbox package on a few NPCs that targets a specific marker in an interior cell. Without Occlusion.esp enabled, this is exactly what happens when I load a new game. The NPC can be found chillin' in that cell.
But with Occlusion.esp enabled, the NPC will be frozen in their default reference location (in Tamriel worldspace).
I've tried to delete random records from Occlusion.esp just to see what's going on, and eventually, after deleting enough records, the NPC sandbox package worked as intended. But looking at those deleted records in xEdit, the only thing that got changed is the TVDT field.
I have absolutely no explanation for why this happening, especially since I've used several iteration of DynDoLOD 3.0 without issue in the past.