Just chiming in here as I am in the process of redoing a STEP-inspired Skyrim load order from scratch with the new patch plus AE content. Thus far, basically everything works except for the NET Framework and the few mods that depend on it. I have installed a few scripted mods and will certainly keep an eye out for crashes related to those. Overall, it's not seeming like a modpocalypse at all (much less so than the transition from LE to SE). I'll be curious to see which Creation Club items cause issues or conflicts as these make up the bulk of the update.
Having used the STEP method from scratch 2-3 times over the years, I highly recommend using additional separators in MO2 (more than what STEP recommends) to categorize mods so things can be more easily swapped in and out.
I decided to go with Re-Engaged ENB, RLO and COT this time instead of the Cathedral method recommended in the guide. I also decided against DyndoLOD so that I don't need to redo that process with every change. No cleaning masters or anything either, as I expect there will be updates pushed out in the coming weeks/months by Bethesda.
If anything breaks I'll just strip out all but the visual mods and test individual scripted mods individually.
I was surprisingly sort of OK with the functionality offered by CC Survival Mode, although I'll be curious to see how it plays with CACO and CCOR (there are patches on the patch hub for both). In an ideal world, I think we'd mod on top of the now-integrated CC Survival Mode rather than run parallel mods like Frostfall, which (while amazing- don't get me wrong) are fairly susceptible to incompatibility. I may be wrong about this.