Check the amount of VRAM you have set in enblocal.ini for your setup. I had similar crashes with both SKSE and ENB because of windows limitations. Eventually I had to CUT and paste the SKSE/skse.ini folder and file into the skyrim data directory to make Skyrim actually use defaultheap properly (removing the skse.ini file from MO completely), as memoryblocks was showing incorrect values to what I had set (768mb set in skse.ini, memoryblocks was showing 512mb). I also crashed when nearing the stupid win10 dx9 vram limit of 4064mb, I was stumped as to whether I should use the value directly given to me through the dx9 vram test, or remove 350mb first (Neovalens advice). So setting the VRAM to 350 lower and raising the ENB reservedmemorysize finally stopped my crashing. ReservedMemorySizeMb=256 VideoMemorySizeMb=3714 You could also screenshot the MO window at the end of your load order, and get a log from the minute you crash (before reopening or running MO).