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I think MO can't And as for OneTweak what does "require fose mean"? I use MO to run my patches, so do I use MO or fose loader to start OneTweak up?

Fallout 3 has a notorious bug: if you alt tab, it makes it so the game cannot be re-maximized; then you have to force close the game and re-launch it. A workaround is the Fake fullscreen mod https://www.nexusmods.com/fallout3/mods/16001/? How it works is Fallout_Fullscreen.exe is run instead of Fallout3.exe But because I use Mod Organizer for other mods, can it run Fallout_Fullscreen.exe instead of Fallout3.exe?