I had the same problem. Do you use English language? I had crashes with Polish language. This problem is caused by delocalised esp. You should use tesvedid and localize it.
Load tesvedit, check Soul Gems Differ, load, right click on esp. I'm not sure, but there should be something like Other > Localization > Language > and then you choose localize. Save changes.
my_summertim's post in Soul Gems Differ mod causing CTD at main menu. was marked as the answer