Okay, so the conversation seems to have settled on what seems to be a reasonable solution to me. However, I've just discovered that one solution advocated before is a no go. You should NOT put the Unofficial Patches in the data folder, unless you plan on ditching Mod Organizer. It seems to break everything. I was getting infinite load screens when trying to enter several cells and no amount of conflict resolution would fix it. I was also getting crashes that weren't present before. I discovered this when I tried to make a vanilla profile to test certain mods that I thought might be causing the issue, but no matter what I tried, I couldn't get the game to load through MO. My normal game profile with tons of mods would load (with subsequent ILS/crashes), but a vanilla profile with just the DLCs and Unofficial Patches would not. I decided to remove the Unofficial Patches from the data folder and reinstall them through MO like normal. After that, I was able to load the vanilla profile with no issues. I then went back to my normal profile (now with the Unofficial Patches installed as regular mods) and suddenly the conflict window was showing a ton of mods that needed to be reordered. I then loaded up my save and tried to enter the nearest cell that was giving me a consistent infinite load screen and the issue was resolved; it loaded up just fine. It seems the problem is that since MO can't account for conflicts with mods installed in the data folder, you can end up with a complete mess in your priority sorting unless you completely ditch MO. Meaning no mixing and matching mods through MO and mods in the data folder. But it also seems to create an even bigger issue, since I can't explain why the vanilla profile wouldn't load, but my normal game profile would (albeit with major problems). Why would that be? Even when I tried to deactivate the Unofficial Paches in order to load just vanilla Skyrim, it wouldn't work. tl;dr - It should be strongly advised to keep all mods out of the data folder when using MO, no matter what. The only exceptions I guess would be the official DLCs, although I'm strongly considering just moving those into MO as mods.