Thanks. I've never had problems with the Skyrim folder being located in Program Files (Steam's default install location). I know it's advised by most of the community and STEP, so I started a fresh install of Steam and Skyrim, this time in its own 'Games' folder in my C drive away from any special folders. I followed the rest of the guide as well. While, unfortunately, the issue wasn't fixed, I see what's happening now. The files that disappear after launching the game are actually still *in* the game folder, but for some reason they're hidden only when the game isn't running. When I launch the game and alt + tab to the desktop, I can see the files in there but only when the game is running. If I quit the game the files aren't visible anymore. I tested this by placing the ENB series .dlls in the game folder and launching the game. I receive the ENB messages on the start menu and when I alt + tab I can see the .dlls in the game folder. When I quit the game a return to the desktop, they're not visible in the game folder anymore but they're still there.