Freyrgjurd

It will be only available if you have files in the Overwrite folder.
 
After you create the mod, it will clean that folder, thus no need /no way to create a mod from there ^^

The game's profile is taken care by the NVIDIA Driver itself.
 
When you open the profile with NVIDIA Inspector, you are just browsing and editing it. Inspector will always load at BASE Profile, so if you want to confirm the changes, close the program, re-open it and browse to TES5 profile again. You changes should be there.
 
It's like this:
 
NVidia Graphics Driver is a library of profiles that NVIDIA itself creates and modify. Inspector gives us the tools to modify them :)
The profile is loaded by the graphics driver everytime you load TESV.exe (through skse.exe too).