None of that is an issue. Its not an issue with MO2 as it works on empty/few mods profiles just fine, skse64 included. Something with my mod setup is at fault, just don't know what or how to figure it out. There are no errors anywhere so it shouldn't fail to run, but it does. A new profile with skse64 and SkyUI works fine. None of the MO files are blocked by windows, everything is set to run as admin, not in program files, not in game folder, no AV or any monitoring programs running, no ENB or other .dll loaders of any sort, all of my tools see all of the mods from the virtual file system and can make changes (bashed and smashed), all mods are up to date as of today, etc.