I've been trying to fix this for a long time, and I had been hoping the last update would fix it but unfortunately I still have this issue. Anyways, having 512 or more plugins (the right pane, and they are *not* activated) causes the game to ctd when I start a new game (whether or not I run it through SKSE). Running the game outside MO (whether it be SkyrimSE.exe, the launcher or SKSE) works fine. The game runs fine when there are 511 or fewer plugins in MO. I haven't been able to find anyone else with this problem and I've run out of ideas.