Thanks for the response. I did have it installed to its own drive, that being said, I fixed it: it was a problem between the seat and the keyboard.
I mistakingly thought that since I had all the plugins in the right pane disabled, that meant that no mods were loading. I didn't think to disable the mods in the left pane as well. Once I did that, F4SE started right up. Afterwards it was just a matter of narrowing down what mod was causing the issue, which turned out to be Def UI. So I'll figure that out.
