Bumping this thread as I have a fairly similar problem. I am working from a clean installation of Skyrim on Windows 10. I have downloaded and installed the ENB core files and patches, changed the skyrimpref.ini file as instructed, and installed OrganicENB v2 but nothing happens when I launch the game. I see the ENB message in the top left corner of the screen but the game remains vanilla. I cannot bring up the ENB GUI either. I have spent quite a bit of time searching for an answer on google but no luck. Does anyone have any ideas? I'm pretty desperate at this point.