Thanks for your help, I hadn't installed ENBoost as I misunderstood and thought that it would take up more resources and reduce performance for the game, not for the system overall. I have installed it, fixed the load order and briefly tested it and it seems to be working (I can walk to Megaton at least now) so thanks very much, have really enjoyed learning more about the guts of the game and am keen to play it now that hopefully it's fixed!