Neither Skyrim, nor MO, are installed on the C: drive, let alone in Program Files. I know how buggy that can make games (and mods especially). As for antivirus software, I hadn't changed any installed files between the time that it was working, and the time that the single mod (not any others around it) stopped responding to mouse clicks. And again, it could be enabled through a key press (space bar), just not through a mouse click. As such, I'd suppose this is some kind of internal issue with the UI, rather than external interference. The mod has also since started working normally again, and once again, I changed nothing in my computer installations. I realized that this was an oddball from the beginning. As I said, I just wanted to give as much information about it as possible as a bug report.