Hi folks
I saw the link to this forum on Nexus. I feel your pain. I feel obliged to let you all know the only thing that ever helped me with CTDs related to high VRAM.
I use mostly 2K textures....a few 4K for some armors and weapons but not much. I would CTD ALL THE TIME...changing cells, exterior to interior cell changes.... even with my specs (below). It got so bad I was scared to enter Keeps or walk into Falkreath for fear of crashes. I was making 30 saves an hour at times to protect progress.
Then I read an article (which I now cannot find) which explained that it is the "revving up" that causes the CTDs...a sudden increase in VRAM will make even a good system stumble. Crashes usually occurred for me when the VRAM increased to around 3.1 or 3.2 from under 2.4
I had used the "Optimizer Texture" program found here:
https://skyrim.nexusmods.com/mods/12801/?tab=2&navtag=%2Fajax%2Fmodfiles%2F%3Fid%3D12801&pUp=1
It worked okay but with limited success. It reduced the number of CTDs but they still occurred. When I was revisiting the Optimizer Texture program for updates I found this by Thorne67:
https://skyrim.nexusmods.com/mods/36124/?
It is a modified .ini and new instructions for Optimizer Textures which did an AMAZING JOB for me of completely stopping CTDs. And I really mean that. I have not had a single CTD since using it 5 days ago. Before running it my textures folder was nearly 11 GB. Now it is 6.3 GB. I only optimized the loose files, not the textures in any .bsa's
THE ONLY issue was that some textures, like grass, some vegetation, and things like SMIM's new fence textures came out with aliased edges. No big deal, I just reinstalled those textures.
You will need both the original Optimizer and Thorne67's file. Simply follow the instructions to the letter in Thorne67's how-to guide. Back up your textures folder to be safe. I hope this helps because being able to enjoy Skyrim without fear of crashing actually makes it fun again!
ONE MORE THING!
For folks with Intel CPUs I Highly recommend Skyrim Project Stability found here:
https://skyrim.nexusmods.com/mods/32363/?
This is a collection of guides, links, and info on how to optimize your whole systems for all games. You will learn how to unpark your CPU, HPET, TES5EDIT Cleaning/Merging, using cleanmem, and more. WARNING! IT IS NOT RECOMMENDED TO UNPARK AN AMD CPU! That said, there are still other things SPS can do for AMD users.
I did not do everything recommended in Skyrim Project Stability but what I did do worked for me, I have zero freezes and a bit better performance as well.
i5-2500K @ 4.2 Ghz
4GB HD 7950 @ 950/1385
8GB Ripjaw RAM 2133mhz
game on 60GB OCZ Agility 3 SSD