I don't know what to say. I've spent a lot of time testing and have narrowed it down to MO. When I launch with the Vanilla launcher or the 4GB launcher outside of MO, hardware AA takes effect. When I launch in MO, it doesn't. I will note however, that the only launcher.exes that works inside MO are the 4GB one and NVSE. The Vanilla.exe just closes MO and launches as if I had never opened it, i.e. if I open the task manager and view the game process it'll read FalloutNV.exe and not FalloutMO.exe. At this point, I am not so worried about forcing AA for an enb or anything like that. I want to figure out what is stopping my Nvidia Hardware (Control Panel or Inspector) from overriding the game settings. I followed the instructions in the video above to the letter, and everything works fine as long as I launch outside of MO. If I launch within MO, it doesn't. Just to be clear, regardless of ENB or not: -4GB launcher outside of MO runs Hardware Overrides. -4Gb launcher launched from MO does not. -NVSE launched outside of MO runs Hardware Overrides. -NVSE launched from MO does not. -FalloutNV.exe outside of MO runs Hardware Overrides. -FalloutNV.exe launched inside of MO closes the application and runs the game without MO. I added the FalloutMO.exe to both Inspector and Nvidia Control Panel, but it had no effect. Despite my tone, I am not trying to indicate that MO is without a doubt the culprit. I just can't figure it out, and I'm getting a bit frustrated. I guess I can make a video, if need be to show what my setup is and how I'm running things, just so you can point out what I'm missing. I should probably install Skyrim and some other supported games to see if the problem persists. BTW, Gopher didn't mention in his video that the newer versions of the ENB dll don't support any Hardware AA. I had remembered that there was one or two older versions that did temporarily, but now the newer ones don't. Actually, since the original posting in this thread, I realized that none of the ENBs I want to use will support Hardware AA. I figured it out by forcing AA via the method in Gohper's video, launching the game outside of MO and getting visual errors. I then loaded the game via MO, and no AA had taken effect.