I was playing on Skyrim for the first time in about a month or two, deleted all my old saves for my current profile to reroll a new character, play for about 20-30 minutes and get a CTD mid-combat or so. Relaunch SKSE to get told a parameter is wrong (something about the number 87) so after some googling, I figure that just restarting the PC would work the problem out. And it did! I was able to launch SKSE! Except... now it isn't finding the mods, or even the saves I had on the profile (using local for all), and even LOOT couldn't seem to understand that I had mods installed. All of my executables are pathing properly, my ModOrganizer folder is not inside the game install, my game install is not in ProgramFiles/(x86). From the troublshooting I did attempt to do, I couldn't seem to find anything that was as specific as my problem, but maybe I didn't look hard enough. Yes, I do boast a fairly big modlist, and the only real issue before tonight was the odd CTD here and there. TL;DR Skyrim was working fine, it crashed, parameters were wrong when relaunching SKSE, restarted tower, now all MO can do is launch Skyrim vanilla without any of my saves.