Or you can try this method. It worked for me, that's why. Check for proper version of .NET Framework At times the solution can be this easy. You need version 4.6 to be specific. (But not necessary) There are other methods too but I would suggest you to read more about them before deciding which one would be best for you. Reference Links: 1. https://www.techwhoop.com/nexus-mod-manager-wont-open/ 2. https://www.reddit.com/r/skyrimmods/comments/5prg93/nmm_nexus_mod_manager_wont_launch_start_no_error/ 3. https://www.tomsguide.com/answers/id-2051152/nexus-mod-manager-work.html