I had the same issue with a list of more than 250 mods. It was solved marvelously following your suggestions: - Activate the memory patch directly on the Data/SKSE/skse.ini file (maybe creating it for the first time). [General] ClearInvalidRegistrations=1 [Memory] DefaultHeapInitialAllocMB=768 ScrapHeapSizeMB=256 - Including the -forcesteamloader in the arguments of SKSE loader in MO. I changed drastically! from a very ugly crash (i had to unplug every time it happened, it was horribly frozen with ugly random pixels) i ended up running a smooth 15h gameplay without a single problem! Kudos to you