Thank you for posting this! After a good chunk of 3 days I thought I was losing my mind. I started having issues as soon as the new build was installed, including Skyrim going south. So I started over with a s completely fresh clean install of Skyrim and all the tools and followed STEP 2.1.0.0 Wiki for the base utility configuration. I kept the mods to only Smoking Hot Load (from Ruffled Feather) because it gives visual cues without having to load or start a new game, and Alternate Start. For anyone else reading this who hasn't experienced it yet, the symptoms (assuming you followed the instructions correctly in the Wiki) are that the base game and DLCs load, SKSE loads, ENBoost loads -- all those are fine (sort of - the SKSE scripts in MO don't load but the base app does). But on running even a new game, no other mods are present. Since Genius384 asked about Defender, I did think to disable it via Policy Editor and tested after a reboot. It made no difference. As soon as I rolled back to the last stable Win 10 build, everything started working again. For others who read this, if you have seen the same problem, go to the Windows 10 Insider Feedback Hub, search for Organizer, and upvote the 2 issues reported there. As much as we all want the memory limit in DX9 to go away, not at the expense of killing mod management.