Ok, so update on the situation. I've found a topic which has a similar problem ( https://forum.step-project.com/topic/8604-mod-organizer-application-wont-start-afterr-running-the-exe/ ) but the given solution doesn't work in this case, at least as far as I understand it. Skyrim folder was not moved, mod organizer has been tried to run in several different locations. Python and .NET have been installed the whole time, as the installers I downloaded from the link in MO requirements told me that a newer version was already installed. Wacom and bamboo applications have been shut down. ModOrganizer.exe still runs as a background process, ModOrganizer.ini won't be created (among all the other files). The log folder is still empty. Reinstalled MO and Skyrim several times. Running with admin rights doesn't change anything, compatibility mode doesnt change anything. I've validated my local files through steam but didn't change a thing. I do get a UAC alert, which i can say yes to. I forgot to mention it's a Windows 10 machine. I've tried to just create a ModOrganizer.ini (empty) and see how that goes but it doesn't change. I tried running the helper.exe which simply states "Untested windows version 10.0 detected! Invalid number of parameters -1" I'm running out of ideas... If nothing will present itself in the next week i'll do a clean install of windows and report back when I have updates