Hello.I have a similar issue. After 3 months without playing the game I tried to finish the modding I started and immediately noticed a 20 to 30 fps decrease on my regular test path from Riverwood to Whiterun with a blank save (I am a CV1/Vorpx, I take FPS Very seriously). I immediately suspected an hardware issue but after enough benchmarks and clean driver installations I was able to tell it wasn't it (I have an 980TI and 4790K), nor was it a setting issue on the control panel. Launching the game through MOD Organizer with every mods unchecked didn't improve the frame-rate, so I assumed my game was broken. After a clean installation of everything (the game, mod organizer etc) I launched the game via the normal launcher as a quick test with settings similar to what I used before (I play in virtual reality so I didn't use anything that would lower my FPS to begin with) and I had my old Frame-rate back. But then I was in for a huge surprise when I installed MOD Organizer and SKSE, launched the game and saw, once again, a 20 to 25 FPS decrease on a totally vanilla MOD Organizer (no lag spikes at all, only the framerate is impacted). I suspected SKSE this time, but no, SKSE wasn't the culprit when launched alone. And finally, after all my troubles I started to suspect MOD Organizer itself, the one and only thing I would never incriminate because it can't lower the FPS. Tests did confirm it was indeed MOD Organizer that was lowering the FPS. It has now been 10 days that I am taking absolutely all my free time to try and fix it and sadly, for the first time, I have absolutely run out of ideas. I do not run any program supposed to improve FPS/etc in the background and obviously I am aware of simple things such as ini locations/user permissions etc. I welcome any idea really as to what is going on.Lately I have come to the conclusion that some program has to interfere somehow but I just can't find any issue at all on what is running on my computer.