Guide:AMD Radeon Adrenalin
From Step Mods | Change The Game
AMD Radeon Adrenalin
The following configuration works well to alleviate stutter during gameplay on higher-end systems. The issue is not caused by poor performance but rather timings in the frame buffer and how it plays with the game engine. These settings may generally apply to all AMD graphics where there is overlap, so give them a try to resolve issues.
SSE Display Tweaks
Try the following settings for SkyrimSE:SSE Display Tweaks:
Fullscreen=false Borderless=true EnableVSync=true EnableTearing=true SwapEffect=flip_sequential
Set the following to your monitor's refresh rate)
MaximumRefreshRate=144 FramerateLimit=144