When to re-run DynDOLOD's script

[Snarkyfork]

Do I need to re-run or regenerate the DynDOLOD assets with TES5Edit every time I add a mod or the load order changes?

[Greg]

You need to re-run or regenerate DynDOLOD if you install, remove, or update any mods that contain LOD assets. You should also re-run or regenerate DynDOLOD if you install, remove, or update any mods that add or update towns/cities or add new areas to Skyrim (like say Falskaar or Wyrmstooth). Note that you can add new areas (Falskaar or Wyrmstooth) without re-running DynDOLOD but these new areas won't have the dynamic distant LOD applied.

[TechAngel85]

No, only when you install a mod that includes exterior objects and LODs for those objects like buildings, new trees, etc.