Difference between portable and normal startup MO2

[Freeza]

Hello! This may be a stupid question but; What is the difference between portable launch and just choosing Skyrim when relaunching MO2? Which one is better?

Thanks in advance!

[Freeza]

And one more thing (since I couldn't edit my post), where to put the files given from MO2 2.0.8.5 ?

[Genius384]

Portable is meant to be a self contained instance dedicated to a single game.  The difference would be where you installed the files, eg. C:\tools\ModOrganizer or C:\games\Skyrim\ModOrganizer

 

I usually like to have dedicated Mod Organizer instances per each game I'm managing, eg. C:\games\steamapps\skyrim\ModOrganizer, C:\games\steamapps\Oblivion\ModOrganizer, etc.