This is a friendly reminder for the Step SkyrimSE Guide users to untick their Cleaned Vanilla Masters mod listing and reclean the game files after updating Skyrim SE on Steam.
If you are experiencing base-game issues after an update (launching issues, CC content redownloading every launch, etc.), be sure to launch the game from Steam and allow it to redownload the CC content, if applicable. Then try launching from MO, as normal.
Keep in mind, the Guide is current broken until all SKSE mods listed in the Guide are updated! This means the game will not likely load with the Guide installed!